Friday, March 14, 2014

Why do some bacteria have GC-rich DNA?

 A longstanding open problem in biology is why the G+C (guanine plus cytosine) content of DNA varies so much across taxonomic groups. In theory, the amounts of the four bases in DNA (adenine, guanine, cytosine, and thymine) should be roughly equal, and regression to the mean should drive all organisms to a genomic G+C content of 50%. That's not what we find. In some organisms, like Mycobacterium tuberculosis, the G+C content is 65%, whereas in others, like Clostridium botulinum (the botulism organism) the G+C content is only 28%.

We know that, in general, G+C content correlates (not perfectly, though) with large genome size, in bacteria. Very low G+C content usually means a smaller genome size, and in fact tiny intracellular parasites and symbionts like Buchnera aphidicola (the aphid endosymbiont) have some of the lowest G+C contents of all (at 23%).

It's not hard to understand the presence of low-GC organisms, since it's well known that most transition mutations are GC-to-AT transitions. The high prevalence of mutations in the direction of A+T has often been called "AT drift."

But some organisms go the other way, developing unusually high G+C content in their genomes, indicating that something must be counteracting AT drift in those organisms.

Recently, a group of Chinese scientists (see Wu et al., "On the molecular mechanism of GC content variation among eubacterial genomes," Biology Direct, 2012, 7:2) has advanced the notion that high G+C content is due, specifically, to the presence of the dnaE2 gene, which codes for a low-fidelity DNA repair polymerase. This gene, they say, drives A:T pairs to become G:C pairs during the low-fidelity DNA repair that goes on in certain bacteria in times of stress. Not all bacteria contain the dnaE2 polymerase. Wu et al. discuss their theory in some detail in a .January 2014 article in the ISME Journal.

In earlier genomic studies of my own, I curated a list of 1373 eubacterial species (in which no species occurs twice), spanning a wide range of G+C values. When I learned of the dnaE2 hypothesis of Wu et al., I decided to check it against my own curated collection of organisms.

The first thing I did was go to UniProt.org and do a search on dnaE2. Some 1882 hits came back in the search, but many hits were for proteins inferred to be DNA polymerase III alpha subunits, not necessarily of the dnaE2 variety. In order to eliminate false positives, I decided to restrict my search to just bonafide dnaE2 entries that have been reviewed. That immediately cut the number of hits down to 77.

But among the 77 hits, some species were listed more than once (due to entries for multiple strains of the organism). I unduplicated the list at the species level and ended up with 60 unique species.

At this point, I wrote a little JavaScript code to check each of the 1373 organisms in my curated list against the 60 known-dnaE2-containing organisms obtained from UniProt. There were 47 matches. The matches are plotted in red in the graph below.

Click image to enlarge. In this plot, genome A+T content (a taxonomic metric) is on the x-axis and coding-region purine content is on the y-axis. (N=1373) The points in red represent organisms that possess a dnaE2 error-prone polyerase. See text for discussion.

This graph plots A+T content (which of course is just one minus the G+C content) on the horizontal axis, against coding-region purine content (A+G) on the vertical axis. (For more information on the significance of coding-region purine content, see my previous posts here and here. It's not important, though, for the present discussion.) Notice that the red points tend to occur on the left side of the graph, in the area of high G+C (low A+T) content. The red dot furthest to the right represents the genome of Saccharophagus degradans. Only 6 out of 47 dnaE2-positive organisms have G+C content below 50% (A+T above 50%). The rest have genomes rich in G+C.

This is, of course, just a quick, informal test (a "sanity check," if you will) of the Wu hypothesis regarding dnaE2 (which is a repair polymerase not needed for normal DNA replication, nor possessed by all bacteria). Various types of sampling errors could invalidate these results. Also, the Wu hypothesis itself is open to criticism on the grounds that correlation does not prove causation. Nevertheless, it's an interesting hypothesis and a random check of 47 dnaE2-positive species in my collection of 1373 organisms tends to provide at least anecdotal verification of the Wu theory that dnaE2 causes drift toward high G+C content.

Of course, Wu's theory does not explain the wide range of G+C contents observed in organisms other than bacteria. (There is no dnaE2 in eukaryotes, for example.) The general notion, however, that genomic G+C content tends to be a reflection of the components of a cell's "repairosome" (the enzyme systems used in repairing DNA) has substantial merit, I think. On that score, be sure to see my earlier analysis of how the presence or absence of an Ogg1 gene influences coding-region purine content.

Here, by the way, are the 47 dnaE2-containing organisms that show up as red dots in the graph above:

Agrobacterium tumefaciens
Agrobacterium vitis
Alkalilimnicola ehrlichii
Anaeromyxobacter dehalogenans
Anaeromyxobacter sp.
Aromatoleum aromaticum
Azoarcus sp.
Bdellovibrio bacteriovorus
Bordetella bronchiseptica
Bordetella parapertussis
Bradyrhizobium sp.
Brucella abortus
Burkholderia mallei
Burkholderia pseudomallei
Caulobacter crescentus
Corynebacterium diphtheriae
Corynebacterium efficiens
Corynebacterium glutamicum
Corynebacterium jeikeium
Dechloromonas aromatica
Gluconobacter oxydans
Hahella chejuensis
Idiomarina loihiensis
Methylococcus capsulatus
Mycobacterium bovis
Mycobacterium tuberculosis
Nocardia farcinica
Propionibacterium acnes
Pseudomonas fluorescens
Pseudomonas mendocina
Pseudomonas putida
Pseudomonas syringae
Ralstonia pickettii
Ralstonia solanacearum
Rhizobium sp.
Rhodopseudomonas palustris
Ruegeria pomeroyi
Saccharophagus degradans
Sinorhizobium medicae
Symbiobacterium thermophilum
Synechocystis sp.
Teredinibacter turnerae
Vibrio parahaemolyticus
Vibrio vulnificus
Xanthomonas axonopodis
Xanthomonas campestris
Xanthomonas oryzae

39 comments:

  1. Hadnt hear about this dnaE2 enzyme, but I will have to check it out to try to give an extra answer to why do some bacteria have a higher G-C conent than others in my thesis.

    So thanks, and Im now following the blog.

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      ๐ข ๐ฌ๐ž๐š๐ซ๐œ๐ก๐ž๐ ๐จ๐ง-๐ฅ๐ข๐ง๐ž ๐ญ๐จ ๐ค๐ง๐จ๐ฐ ๐š๐ง๐ ๐ž๐ง๐ช๐ฎ๐ข๐ซ๐ž๐ซ ๐š๐›๐จ๐ฎ๐ญ ๐œ๐ฎ๐ซ๐ž ๐Ÿ๐จ๐ซ ๐‡๐„๐‘๐๐„๐’ ๐š๐ง๐ ๐ข ๐ ๐จ๐ญ ๐š
      ๐ญ๐ž๐ฌ๐ญ๐ข๐ฆ๐จ๐ง๐ฒ ๐ฉ๐จ๐ฌ๐ญ๐ž๐ ๐›๐ฒ ๐ƒ๐ซ ๐€๐ฃ๐ž๐ ๐ก๐ž ๐ฉ๐š๐ญ๐ข๐ž๐ง๐ญ ๐จ๐ง ๐ก๐จ๐ฐ ๐ฌ๐ก๐ž ๐ฐ๐š๐ฌ ๐œ๐ฎ๐ซ๐ž๐ ๐Ÿ๐ซ๐จ๐ฆ ๐‡๐’๐•-๐Ÿ ๐ฌ๐จ ๐ข ๐๐ž๐œ๐ข๐๐ž๐ ๐ญ๐จ ๐œ๐จ๐ง๐ญ๐š๐œ๐ญ
      ๐ญ๐ก๐ž ๐ฌ๐š๐ฆ๐ž ๐ก๐ž๐ซ๐›๐š๐ฅ๐ข๐ฌ๐ญ ๐ƒ๐ซ ๐€๐ฃ๐ž๐ ๐ก๐ž ๐›๐ž๐œ๐š๐ฎ๐ฌ๐ž ๐ข ๐ค๐ง๐จ๐ฐ ๐ญ๐ก๐š๐ญ ๐ง๐š๐ญ๐ฎ๐ซ๐ž ๐ก๐š๐ฌ ๐ญ๐ก๐ž ๐ฉ๐จ๐ฐ๐ž๐ซ
      ๐ญ๐จ ๐ก๐ž๐š๐ฅ ๐ž๐ฏ๐ž๐ซ๐ฒ๐ญ๐ก๐ข๐ง๐ .
      ๐ข ๐œ๐จ๐ง๐ญ๐š๐œ๐ญ๐ž๐ ๐ก๐ข๐ฆ ๐ญ๐จ ๐ค๐ง๐จ๐ฐ ๐ก๐จ๐ฐ ๐ก๐ž ๐œ๐š๐ง ๐ก๐ž๐ฅ๐ฉ ๐ฆ๐ž ๐š๐ง๐ ๐ก๐ž ๐ญ๐จ๐ฅ๐ ๐ฆ๐ž ๐ง๐ž๐ฏ๐ž๐ซ ๐ญ๐จ ๐ฐ๐จ๐ซ๐ซ๐ฒ
      ๐ญ๐ก๐š๐ญ ๐ก๐ž ๐ฐ๐ข๐ฅ๐ฅ ๐ก๐ž๐ฅ๐ฉ ๐ฆ๐ž ๐ฐ๐ข๐ญ๐ก ๐ญ๐ก๐ž ๐ง๐š๐ญ๐ฎ๐ซ๐š๐ฅ ๐ก๐ž๐ซ๐›๐ฌ ๐œ๐ซ๐ž๐š๐ญ๐ž๐ ๐›๐ฒ ๐†๐จ๐ ๐€๐ฅ๐ฆ๐ข๐ ๐ก๐ญ๐ฒ!
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      ๐ข ๐ฎ๐ฌ๐ž๐ ๐ญ๐ก๐ž ๐ฆ๐ž๐๐ข๐œ๐ข๐ง๐ž ๐š๐ฌ ๐ก๐ž ๐ข๐ง๐ฌ๐ญ๐ซ๐ฎ๐œ๐ญ๐ž๐ ๐ฆ๐ž (๐Œ๐Ž๐‘๐๐ˆ๐๐† ๐š๐ง๐ ๐„๐•๐„๐๐ˆ๐๐†) ๐š๐ง๐ ๐ข ๐ฐ๐š๐ฌ
      ๐œ๐ฎ๐ซ๐ž๐!
      ๐ข๐ญ๐ฌ ๐ซ๐ž๐š๐ฅ๐ฅ๐ฒ ๐ฅ๐ข๐ค๐ž ๐š ๐๐ซ๐ž๐š๐ฆ ๐›๐ฎ๐ญ ๐ข ๐š๐ฆ ๐ฌ๐จ ๐ก๐š๐ฉ๐ฉ๐ฒ ๐ง๐จ๐ฐ!
      ๐ญ๐ก๐š๐ญ'๐ฌ ๐ญ๐ก๐ž ๐ซ๐ž๐š๐ฌ๐จ๐ง ๐ข ๐๐ž๐œ๐ข๐๐ž๐ ๐ญ๐จ ๐š๐ฅ๐ฌ๐จ ๐š๐๐ ๐ฆ๐จ๐ซ๐ž ๐œ๐จ๐ฆ๐ฆ๐ž๐ง๐ญ ๐จ๐Ÿ ๐‡๐ข๐ฆ ๐ฌ๐จ ๐ญ๐ก๐š๐ญ ๐ฆ๐จ๐ซ๐ž ๐œ๐š๐ง
      ๐›๐ž ๐ฌ๐š๐ฏ๐ž๐ ๐ฃ๐ฎ๐ฌ๐ญ ๐ฅ๐ข๐ค๐ž ๐ฆ๐ž!
      ๐š๐ง๐ ๐ข๐Ÿ ๐ฒ๐จ๐ฎ ๐ง๐ž๐ž๐ ๐ก๐ข๐ฌ ๐ก๐ž๐ฅ๐ฉ, ๐ฒ๐จ๐ฎ ๐œ๐š๐ง ๐ž๐ฆ๐š๐ข๐ฅ ๐ก๐ข๐ฆ ๐จ๐ง ๐›๐š๐›๐š๐š๐ฃ๐ž๐ ๐ก๐ž๐ฌ๐ก๐ซ๐ข๐ง๐ž@๐ ๐ฆ๐š๐ข๐ฅ.๐œ๐จ๐ฆ
      ๐จ๐ซ ๐ฐ๐ก๐š๐ญ๐ฌ-๐š๐ฉ๐ฉ +๐Ÿ๐Ÿ‘๐Ÿ’๐Ÿ•๐ŸŽ๐Ÿ–๐Ÿ‘๐Ÿ—๐Ÿ–๐Ÿ’๐Ÿ’๐Ÿ—๐Ÿ’
      ๐ˆ'๐ฆ ๐ฏ๐ž๐ซ๐ข๐ญ๐š ๐‘๐จ๐›๐ž๐ซ๐ญ๐ฌ ๐š๐ง๐ ๐ฒ๐จ๐ฎ ๐œ๐š๐ง ๐ ๐ž๐ญ ๐ข๐ง ๐ญ๐จ๐ฎ๐œ๐ก ๐ฐ๐ข๐ญ๐ก ๐ฆ๐ž ๐ฏ๐ข๐š ๐ฆ๐š๐ข๐ฅ / ๐ข๐ง๐ฌ๐ญ๐š๐ ๐ซ๐š๐ฆ (@๐ฏ๐ž๐ซ๐ข๐ญ๐š๐ซ๐จ๐›๐ž๐ซ๐ญ) ๐ฏ๐ž๐ซ๐ข๐ญ๐š๐ซ๐จ๐›๐Ÿ๐Ÿ•@๐ ๐ฆ๐š๐ข๐ฅ.๐œ๐จ๐ฆ

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      contact which is just to give him a test I spoke to him, he told me that
      there is no medical hospital that has the cure to HERPES, i was supprise
      when i heard that from, he asked me to do some certain things which I did
      he told me that he is going to provide the herbal cure to me which he did
      then he asked me to go for medical checkup after some days after using the
      herbal cure behold I was free from the deadly disease, he only asked me to
      post the testimony through the whole world, faithfully am doing it now
      please BROTHER, SISTER, MOTHER and FATHER he is great a great man, I owe
      him in return.if you are having a similar problem just email him Via:
      drehbos@gmail.com or you can Whatsapp him Via:
      +2348133505254
      websites;; https://drehbos.wixsite.com/drehbosherbalcenter
      EmaIl address;; drehbos@gmail.com

      Delete
    4. I’m recommending Dr Godday to everyone who have herpes virus to get the cure from him. I was diagnose of genital herpes in 2015 and i have been searching and asking questions to see if i could get something to cure the disease because i did not believe what the doctors say that no cure is found yet. I came across a comment on Youtube and the person testify how she was cured from herpes and hpv after using Dr Godday herbal medicine. I quickly contact Dr email and explain my problem to him and he prepare the herbs and send it to me through courier and gave me instructions on how to use it and tell me to go for checkup after usage which i did after two weeks of taken the herbal medicine and my result was NEGATIVE. I waited another month and retested the result was still NEGATIVE and my doctor told me that am completely free from herpes. Am so happy and grateful to Dr Godday for what he has done for me and i will continue to share this for people out there to know that there is cure for herpes. You can contact Dr Godday on email and WhatsApp to get the cure from him. Email:goddayspiritualhome@gmail.com Or Call/What’s-app +1{919}4956404

      Delete
    5. Good news this is to everyone out there with different health challenges, as I know there are still a lot of people suffering from different health issues and are therefore looking for solutions. I bring you Good news. There is a man called Dr ehiaguna a herbal practitioner who helped cure me from HSV (2), i had suffered from this diseases for the past 5 years and i have spent so much money trying to survive from it. I got my healing by taking the herbal medicine Dr ehiaguna sent to me to drink for about 14 days . 3 days after completion of the dosage, I went for a medical checkup and I was tested free from HSV. all thanks to God for leading me to Dr ehiaguna who was able to cure me completely from this deadly diseases, I’m sharing this so that other people can know of this great healer called Dr ehiaguna because I got to know him through elizabeth who he cured from HIV. I was made to understand that he can cure several other deadly diseases and infections. Don’t die in ignorance or silent and don’t let that illness take your life. Contact Dr ehiaguna through his email drehiaguna@gmail.com You can also whatsapp/call him on:+2348073908953 .He cure all forms of disease {1}HIV/AIDS {2}DIABETES {3}EPILEPSY {4} BLOOD CANCER {5} HPV {6} BRAIN TUMOR {7} HEPATITIS {8}COPD{9} SICKLE AND ANAEMIA.etc Be kind enough to share as you received.

      Delete
  2. we are exciting to find that several bacterial of smaller genome sizes also have higher GC contents and extra copies of dnaE2, confirming the contribution of dnaE2 to gc content variations. by the way, there are indeed gc-driving repair polymerases in eukarytes but just not homologs of dnaE2.

    ReplyDelete
  3. Greetings to the general public, Am Mike Amos i want to inform the public how i was cured of HERPES Simplex Virus by a Doctor called Ero. i visited different hospital but they gave me list of drugs like Famvir, Zovirax, and Valtrex which is very expensive to treat the symptoms and never cured me. I was browsing through the Internet searching for remedy on HERPES and i saw comment of people talking about how Doctor Ero cured them. I Was scared because i never believed in the Internet but i was convince to give him a try because i was having no hope of been cured of HERPES so i decided to contact him on his email that was listed on the comment (dreroherbaltreatment@gmail.com ) i searched his email on net and i saw a lot of people testifying about his goodness. when i contacted him he gave me hope and send a Herbal medicine to me that i took and it seriously worked for me, am a free person now without problem, my HERPES result came out negative. I pray for you Dr Ero God will give you everlasting life, you shall not die before your time for being a sincere and great men. Am so happy, you can also contact him if you have any problem Email: dreroherbaltreatment@gmail.com.

    ReplyDelete
    Replies
    1. I found out, that taking herbal treatment is the best to get rid of hpv as soon as i feel the symptoms of hpv is appearing, i took the healing process by contacting Dr Oyagu for natural treatment it works wonders, amazingly ever since I had the herbal treatment i have not feel these horrible disease anymore and my doc told me the virus is gone, i am glad i finally got cured out from this horrible disease. every hpv or herpes patients should also get in touch with this herbalist Dr to get ride of these disease forever his email address:Oyguspellcaster@gmail.com or wahtsapp +2348101755322 thank you.....

      Delete
  4. With outstanding gameplay and also discussion NBA2K18 Basketball excitement game to be played on android.

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  5. Much in the same way you share points with a therapist snapchat sign in that are no longer relevant But, like most of one of the most preferred apps.

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  6. Don't be held hostage by annoying surveys, just to view premium content. Free solution to bypass surveys. learn the best ways on how to bypass surveys on 2018.

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  7. Replies
    1. I found out, that taking herbal treatment is the best to get rid of hpv as soon as i feel the symptoms of hpv is appearing, i took the healing process by contacting Dr Oyagu for natural treatment it works wonders, amazingly ever since I had the herbal treatment i have not feel these horrible disease anymore and my doc told me the virus is gone, i am glad i finally got cured out from this horrible disease. every hpv or herpes patients should also get in touch with this herbalist Dr to get ride of these disease forever his email address:Oyguspellcaster@gmail.com or wahtsapp +2348101755322 thank you.....

      Delete
  8. Hello Everyone out there,I am here to give my testimony about a Herbalist doctor who helped me . I was infected with HERPES SIMPLEX VIRUS in 2011, i went to many hospitals for cure but there was no solution, so I was thinking how can I get a solution out so that my body can be okay. One day I was in the river side thinking where I can go to get solution. so a lady walked to me telling me why am I so sad and i open up all to her telling her my problem, she told me that she can help me out, she introduce me to a doctor who uses herbal medication to cure HERPES SIMPLEX VIRUS and gave me his email, so i mail him. He told me all the things I need to do and also give me instructions to take, which I followed properly. Before I knew what is happening after two weeks the HERPES SIMPLEX VIRUS that was in my body got vanished . so if you are also heart broken and also need a help, you can also email him at {oliha.miraclemedicine@gmail.com}
    or whatsapp him number: +2349038382931.

    Contact him today and you will have a testimony...Good luck!

    Dr. OLIHA Also Cures:
    1. HIV/AIDS
    2. HERPES 1/2
    3. CANCER
    4. ALS (Lou Gehrigรข€™s disease)
    5. Hepatitis B
    6. chronic pancreatic
    7. Emphysema
    8. COPD (Chronic Obstructive Pulmonary Disease ....

    ReplyDelete
  9. I was haven herpes 2 on my private part. I have had them for about 2 and a bit years. I am so scared what my mates are going to says if there should fined out i have herpes on my private part and due to the virus my girlfriend broke up with me. I have been to the Doctors 9 times to get it treated. They all come back. I have been using Tee Tree Oil and Wartner (You freeze them at home) and they seem to be keeping the smaller herpes small but they can't seem to treat the larger ones. They don't get any bigger, but then they can't shrink as much. They get smaller a little part at a time. At least they are getting smaller! As soon as I see a new herpes appearing, then I treat it. At the moment I have been using Tee Tree twice a week and then using Wartner every 2 weeks. I was wondering if there was any other information about how to get rid of it. I am only a teenager and I hate it most when it get pi-chins me to scratch it, it get sweets when scratching it most times! I want to get rid of it so bad! DR.ONOKUN website has been a huge help and has helped me realize a lot more about me and my family of genital herpes! so that was when i switch for natural remedy to see if there could be any help by herbal remedy, i search and i saw a great posts by Sarah devise adebayo ehijactor and shanttel Merritt on about the great herbal doctor that get them rid of there disease infection. and this great herbal doctor was called DR.ONOKUN so that was when i contacted him for my own treatment and he prepared me some herbs which i takes for some couples of days, and i take it as he says before i am to no me and my family was perfectly cure for it and never experience it again. please friends if you have herpes virus and you really wants to get rid of it, please contact this great DR.ONOKUN for herbal treatment and you will get rid of it. EMAIL. dronokunherbalcure@gmail.com 

    ReplyDelete
  10. I was haven herpes 2 on my private part. I have had them for about 2 and a bit years. I am so scared what my mates are going to says if there should fined out i have herpes on my private part and due to the virus my girlfriend broke up with me. I have been to the Doctors 9 times to get it treated. They all come back. I have been using Tee Tree Oil and Wartner (You freeze them at home) and they seem to be keeping the smaller herpes small but they can't seem to treat the larger ones.
    BACTERIA

    ReplyDelete
  11. God bless Dr. AIGBOMIAN for his marvelous work in my life, I was diagnosed of HERPES since 2010 and I was taking my medications, I wasn't satisfied i needed to get the HERPES. out of my system, I searched about some possible cure for HERPES i saw a comment about Dr. AIGBOMIAN, how he cured HERPES with his herbal medicine, I contacted him and he guided me. I asked for solutions, he started the remedy for my health, he sent me the medicine through UPS SPEED POST. I took the medicine as prescribed by him and 8 days later i was cured from HERPES/
    ,thank you Dr AIGBOMIAN ONCE AGAIN THANK YOU SIR
    Dr AIGBOMIAN cure the flowing virus, add his Africa branch on whatsapp and calls +2348116963033
    1 cancer cure
    2 diabetes cure
    3 ringing ear
    4 herpes cure
    5 warts cure
    6 HPV cure
    7 Hiv
    8 get your ex back
    9 pregnancy herbal medicine
    10 prostate enlargement
    11 Hepatitis B
    You can also email him on: draigbomianherbalhome@gmail.com

    ReplyDelete
  12. I found out, that taking herbal treatment is the best to get rid of hpv as soon as i feel the symptoms of hpv is appearing, i took the healing process by contacting Dr Oyagu for natural treatment it works wonders, amazingly ever since I had the herbal treatment i have not feel these horrible disease anymore and my doc told me the virus is gone, i am glad i finally got cured out from this horrible disease. every hpv or herpes patients should also get in touch with this herbalist Dr to get ride of these disease forever his email address:Oyguspellcaster@gmail.com or wahtsapp +2348101755322 thank you.....

    ReplyDelete
  13. I am here to give my testimony about Dr Ebhota who helped me.. i want to inform the public how i was cured from (HERPES SIMPLEX VIRUS) by salami, i visited different hospital but they gave me list of drugs like Famvir, Zovirax, and Valtrex which is very expensive to treat the symptoms and never cured me. I was browsing through the Internet searching for remedy on HERPES and i saw comment of people talking about how Dr Ehbota cured them. when i contacted him he gave me hope and send a Herbal medicine to me that i took for just 2 weeks and it seriously worked for me, my HERPES result came out negative. I am so happy as i am sharing this testimony. My advice to you all who thinks that there is no cure for herpes that is Not true just contact him and get cure from Dr Ebhota healing herbal cure of all kinds of sickness you may have like
    (1) CANCER,
    (2) DIABETES,
    (3) HIV&AIDS,
    (4) URINARY TRACT INFECTION,
    (5) CANCER,
    (6) IMPOTENCE,
    (7) BARENESS/INFERTILITY
    (8) DIARRHEA
    (9) ASTHMA
    (10)SIMPLEX HERPES AND GENITAL
    (11)COLD SORE
    HERPES. he also cure my friend from cervical cancer Email: drebhotasoultion@gmail.com or whatsapp him on +2348089535482

    ReplyDelete
  14. ๐‡๐š๐ฏ๐ข๐ง๐  ๐ก๐ž๐ซ๐ฉ๐ž๐ฌ ๐จ๐ซ ๐š๐ง๐ฒ ๐ค๐ข๐ง๐ ๐จ๐Ÿ ๐ฌ๐ข๐œ๐ค๐ง๐ž๐ฌ๐ฌ/ ๐๐ข๐ฌ๐ž๐š๐ฌ๐ž ๐ข๐ฌ ๐ง๐จ๐ญ ๐ญ๐ก๐ž ๐ž๐ง๐ ๐จ๐Ÿ ๐ฅ๐ข๐Ÿ๐ž ๐ญ๐ก๐ž๐ซ๐ž ๐š๐ซ๐ž ๐ญ๐ซ๐ž๐š๐ญ๐ฆ๐ž๐ง๐ญ ๐ญ๐จ ๐ ๐ž๐ญ ๐ซ๐ข๐ ๐จ๐Ÿ ๐†๐ž๐ง๐ข๐ญ๐š๐ฅ ๐ก๐ž๐ซ๐ฉ๐ž๐ฌ / ๐๐ข๐ฌ๐ž๐š๐ฌ๐ž ๐ฐ๐ข๐ญ๐ก ๐ญ๐ซ๐š๐๐ข๐ญ๐ข๐จ๐ง๐š๐ฅ ๐ก๐ž๐ซ๐›๐ฌ ๐Ÿ๐ซ๐จ๐ฆ ๐ƒ๐ซ ๐€๐ฃ๐ž๐ ๐ก๐ž.
    ๐ˆ ๐ฐ๐š๐ฌ ๐ฉ๐จ๐ฌ๐ข๐ญ๐ข๐ฏ๐ž ๐ญ๐จ ๐ญ๐ก๐ข๐ฌ ๐ข๐ง๐Ÿ๐ž๐œ๐ญ๐ข๐จ๐ง (๐‡๐„๐‘๐๐„๐’) ๐š๐ง๐ ๐ข ๐ฅ๐จ๐ฌ๐ญ ๐ก๐จ๐ฉ๐ž ๐›๐ž๐œ๐š๐ฎ๐ฌ๐ž ๐ข
    ๐ฐ๐š๐ฌ ๐จ๐ฎ๐ญ ๐œ๐š๐ฌ๐ญ ๐š๐ง๐ ๐ซ๐ž๐ฃ๐ž๐œ๐ญ๐ž๐ ๐ž๐ฏ๐ž๐ง ๐›๐ฒ ๐ฆ๐ฒ ๐œ๐ฅ๐จ๐ฌ๐ž๐ญ ๐Ÿ๐ซ๐ข๐ž๐ง๐๐ฌ.
    ๐ข ๐ฌ๐ž๐š๐ซ๐œ๐ก๐ž๐ ๐จ๐ง-๐ฅ๐ข๐ง๐ž ๐ญ๐จ ๐ค๐ง๐จ๐ฐ ๐š๐ง๐ ๐ž๐ง๐ช๐ฎ๐ข๐ซ๐ž๐ซ ๐š๐›๐จ๐ฎ๐ญ ๐œ๐ฎ๐ซ๐ž ๐Ÿ๐จ๐ซ ๐‡๐„๐‘๐๐„๐’ ๐š๐ง๐ ๐ข ๐ ๐จ๐ญ ๐š
    ๐ญ๐ž๐ฌ๐ญ๐ข๐ฆ๐จ๐ง๐ฒ ๐ฉ๐จ๐ฌ๐ญ๐ž๐ ๐›๐ฒ ๐ƒ๐ซ ๐€๐ฃ๐ž๐ ๐ก๐ž ๐ฉ๐š๐ญ๐ข๐ž๐ง๐ญ ๐จ๐ง ๐ก๐จ๐ฐ ๐ฌ๐ก๐ž ๐ฐ๐š๐ฌ ๐œ๐ฎ๐ซ๐ž๐ ๐Ÿ๐ซ๐จ๐ฆ ๐‡๐’๐•-๐Ÿ ๐ฌ๐จ ๐ข ๐๐ž๐œ๐ข๐๐ž๐ ๐ญ๐จ ๐œ๐จ๐ง๐ญ๐š๐œ๐ญ
    ๐ญ๐ก๐ž ๐ฌ๐š๐ฆ๐ž ๐ก๐ž๐ซ๐›๐š๐ฅ๐ข๐ฌ๐ญ ๐ƒ๐ซ ๐€๐ฃ๐ž๐ ๐ก๐ž ๐›๐ž๐œ๐š๐ฎ๐ฌ๐ž ๐ข ๐ค๐ง๐จ๐ฐ ๐ญ๐ก๐š๐ญ ๐ง๐š๐ญ๐ฎ๐ซ๐ž ๐ก๐š๐ฌ ๐ญ๐ก๐ž ๐ฉ๐จ๐ฐ๐ž๐ซ
    ๐ญ๐จ ๐ก๐ž๐š๐ฅ ๐ž๐ฏ๐ž๐ซ๐ฒ๐ญ๐ก๐ข๐ง๐ .
    ๐ข ๐œ๐จ๐ง๐ญ๐š๐œ๐ญ๐ž๐ ๐ก๐ข๐ฆ ๐ญ๐จ ๐ค๐ง๐จ๐ฐ ๐ก๐จ๐ฐ ๐ก๐ž ๐œ๐š๐ง ๐ก๐ž๐ฅ๐ฉ ๐ฆ๐ž ๐š๐ง๐ ๐ก๐ž ๐ญ๐จ๐ฅ๐ ๐ฆ๐ž ๐ง๐ž๐ฏ๐ž๐ซ ๐ญ๐จ ๐ฐ๐จ๐ซ๐ซ๐ฒ
    ๐ญ๐ก๐š๐ญ ๐ก๐ž ๐ฐ๐ข๐ฅ๐ฅ ๐ก๐ž๐ฅ๐ฉ ๐ฆ๐ž ๐ฐ๐ข๐ญ๐ก ๐ญ๐ก๐ž ๐ง๐š๐ญ๐ฎ๐ซ๐š๐ฅ ๐ก๐ž๐ซ๐›๐ฌ ๐œ๐ซ๐ž๐š๐ญ๐ž๐ ๐›๐ฒ ๐†๐จ๐ ๐€๐ฅ๐ฆ๐ข๐ ๐ก๐ญ๐ฒ!
    ๐š๐Ÿ๐ญ๐ž๐ซ ๐Ÿ ๐๐š๐ฒ๐ฌ ๐จ๐Ÿ ๐œ๐จ๐ง๐ญ๐š๐œ๐ญ๐ข๐ง๐  ๐ก๐ข๐ฆ, ๐ก๐ž ๐ญ๐จ๐ฅ๐ ๐ฆ๐ž ๐ญ๐ก๐š๐ญ ๐ญ๐ก๐ž ๐œ๐ฎ๐ซ๐ž ๐ก๐š๐ฌ ๐›๐ž๐ž๐ง ๐ฉ๐ซ๐ž๐ฉ๐š๐ซ๐ž ๐š๐ง๐
    ๐ก๐ž ๐ฐ๐ข๐ฅ๐ฅ ๐ฌ๐ž๐ง๐ ๐ข๐ญ ๐ญ๐จ ๐ฆ๐ž ๐ฏ๐ข๐š (๐…๐ž๐๐„๐ฑ ๐ƒ๐ž๐ฅ๐ข๐ฏ๐ž๐ซ๐ฒ ๐ฌ๐ž๐ซ๐ฏ๐ข๐œ๐ž)๐š๐ง๐ ๐ข๐ญ ๐ ๐จ๐ญ ๐ญ๐จ ๐ฆ๐ž ๐š๐Ÿ๐ญ๐ž๐ซ ๐Ÿ‘ ๐๐š๐ฒ๐ฌ!
    ๐ข ๐ฎ๐ฌ๐ž๐ ๐ญ๐ก๐ž ๐ฆ๐ž๐๐ข๐œ๐ข๐ง๐ž ๐š๐ฌ ๐ก๐ž ๐ข๐ง๐ฌ๐ญ๐ซ๐ฎ๐œ๐ญ๐ž๐ ๐ฆ๐ž (๐Œ๐Ž๐‘๐๐ˆ๐๐† ๐š๐ง๐ ๐„๐•๐„๐๐ˆ๐๐†) ๐š๐ง๐ ๐ข ๐ฐ๐š๐ฌ
    ๐œ๐ฎ๐ซ๐ž๐!
    ๐ข๐ญ๐ฌ ๐ซ๐ž๐š๐ฅ๐ฅ๐ฒ ๐ฅ๐ข๐ค๐ž ๐š ๐๐ซ๐ž๐š๐ฆ ๐›๐ฎ๐ญ ๐ข ๐š๐ฆ ๐ฌ๐จ ๐ก๐š๐ฉ๐ฉ๐ฒ ๐ง๐จ๐ฐ!
    ๐ญ๐ก๐š๐ญ'๐ฌ ๐ญ๐ก๐ž ๐ซ๐ž๐š๐ฌ๐จ๐ง ๐ข ๐๐ž๐œ๐ข๐๐ž๐ ๐ญ๐จ ๐š๐ฅ๐ฌ๐จ ๐š๐๐ ๐ฆ๐จ๐ซ๐ž ๐œ๐จ๐ฆ๐ฆ๐ž๐ง๐ญ ๐จ๐Ÿ ๐‡๐ข๐ฆ ๐ฌ๐จ ๐ญ๐ก๐š๐ญ ๐ฆ๐จ๐ซ๐ž ๐œ๐š๐ง
    ๐›๐ž ๐ฌ๐š๐ฏ๐ž๐ ๐ฃ๐ฎ๐ฌ๐ญ ๐ฅ๐ข๐ค๐ž ๐ฆ๐ž!
    ๐š๐ง๐ ๐ข๐Ÿ ๐ฒ๐จ๐ฎ ๐ง๐ž๐ž๐ ๐ก๐ข๐ฌ ๐ก๐ž๐ฅ๐ฉ, ๐ฒ๐จ๐ฎ ๐œ๐š๐ง ๐ž๐ฆ๐š๐ข๐ฅ ๐ก๐ข๐ฆ ๐จ๐ง ๐›๐š๐›๐š๐š๐ฃ๐ž๐ ๐ก๐ž๐ฌ๐ก๐ซ๐ข๐ง๐ž@๐ ๐ฆ๐š๐ข๐ฅ.๐œ๐จ๐ฆ
    ๐จ๐ซ ๐ฐ๐ก๐š๐ญ๐ฌ-๐š๐ฉ๐ฉ +๐Ÿ๐Ÿ‘๐Ÿ’๐Ÿ•๐ŸŽ๐Ÿ–๐Ÿ‘๐Ÿ—๐Ÿ–๐Ÿ’๐Ÿ’๐Ÿ—๐Ÿ’
    ๐ˆ'๐ฆ ๐ฏ๐ž๐ซ๐ข๐ญ๐š ๐‘๐จ๐›๐ž๐ซ๐ญ๐ฌ ๐š๐ง๐ ๐ฒ๐จ๐ฎ ๐œ๐š๐ง ๐ ๐ž๐ญ ๐ข๐ง ๐ญ๐จ๐ฎ๐œ๐ก ๐ฐ๐ข๐ญ๐ก ๐ฆ๐ž ๐ฏ๐ข๐š ๐ฆ๐š๐ข๐ฅ / ๐ข๐ง๐ฌ๐ญ๐š๐ ๐ซ๐š๐ฆ (@๐ฏ๐ž๐ซ๐ข๐ญ๐š๐ซ๐จ๐›๐ž๐ซ๐ญ) ๐ฏ๐ž๐ซ๐ข๐ญ๐š๐ซ๐จ๐›๐Ÿ๐Ÿ•@๐ ๐ฆ๐š๐ข๐ฅ.๐œ๐จ๐ฆ

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  15. ๐‡๐š๐ฏ๐ข๐ง๐  ๐ก๐ž๐ซ๐ฉ๐ž๐ฌ ๐จ๐ซ ๐š๐ง๐ฒ ๐ค๐ข๐ง๐ ๐จ๐Ÿ ๐ฌ๐ข๐œ๐ค๐ง๐ž๐ฌ๐ฌ/ ๐๐ข๐ฌ๐ž๐š๐ฌ๐ž ๐ข๐ฌ ๐ง๐จ๐ญ ๐ญ๐ก๐ž ๐ž๐ง๐ ๐จ๐Ÿ ๐ฅ๐ข๐Ÿ๐ž ๐ญ๐ก๐ž๐ซ๐ž ๐š๐ซ๐ž ๐ญ๐ซ๐ž๐š๐ญ๐ฆ๐ž๐ง๐ญ ๐ญ๐จ ๐ ๐ž๐ญ ๐ซ๐ข๐ ๐จ๐Ÿ ๐†๐ž๐ง๐ข๐ญ๐š๐ฅ ๐ก๐ž๐ซ๐ฉ๐ž๐ฌ / ๐๐ข๐ฌ๐ž๐š๐ฌ๐ž ๐ฐ๐ข๐ญ๐ก ๐ญ๐ซ๐š๐๐ข๐ญ๐ข๐จ๐ง๐š๐ฅ ๐ก๐ž๐ซ๐›๐ฌ ๐Ÿ๐ซ๐จ๐ฆ ๐ƒ๐ซ ๐€๐ฃ๐ž๐ ๐ก๐ž.
    ๐ˆ ๐ฐ๐š๐ฌ ๐ฉ๐จ๐ฌ๐ข๐ญ๐ข๐ฏ๐ž ๐ญ๐จ ๐ญ๐ก๐ข๐ฌ ๐ข๐ง๐Ÿ๐ž๐œ๐ญ๐ข๐จ๐ง (๐‡๐„๐‘๐๐„๐’) ๐š๐ง๐ ๐ข ๐ฅ๐จ๐ฌ๐ญ ๐ก๐จ๐ฉ๐ž ๐›๐ž๐œ๐š๐ฎ๐ฌ๐ž ๐ข
    ๐ฐ๐š๐ฌ ๐จ๐ฎ๐ญ ๐œ๐š๐ฌ๐ญ ๐š๐ง๐ ๐ซ๐ž๐ฃ๐ž๐œ๐ญ๐ž๐ ๐ž๐ฏ๐ž๐ง ๐›๐ฒ ๐ฆ๐ฒ ๐œ๐ฅ๐จ๐ฌ๐ž๐ญ ๐Ÿ๐ซ๐ข๐ž๐ง๐๐ฌ.
    ๐ข ๐ฌ๐ž๐š๐ซ๐œ๐ก๐ž๐ ๐จ๐ง-๐ฅ๐ข๐ง๐ž ๐ญ๐จ ๐ค๐ง๐จ๐ฐ ๐š๐ง๐ ๐ž๐ง๐ช๐ฎ๐ข๐ซ๐ž๐ซ ๐š๐›๐จ๐ฎ๐ญ ๐œ๐ฎ๐ซ๐ž ๐Ÿ๐จ๐ซ ๐‡๐„๐‘๐๐„๐’ ๐š๐ง๐ ๐ข ๐ ๐จ๐ญ ๐š
    ๐ญ๐ž๐ฌ๐ญ๐ข๐ฆ๐จ๐ง๐ฒ ๐ฉ๐จ๐ฌ๐ญ๐ž๐ ๐›๐ฒ ๐ƒ๐ซ ๐€๐ฃ๐ž๐ ๐ก๐ž ๐ฉ๐š๐ญ๐ข๐ž๐ง๐ญ ๐จ๐ง ๐ก๐จ๐ฐ ๐ฌ๐ก๐ž ๐ฐ๐š๐ฌ ๐œ๐ฎ๐ซ๐ž๐ ๐Ÿ๐ซ๐จ๐ฆ ๐‡๐’๐•-๐Ÿ ๐ฌ๐จ ๐ข ๐๐ž๐œ๐ข๐๐ž๐ ๐ญ๐จ ๐œ๐จ๐ง๐ญ๐š๐œ๐ญ
    ๐ญ๐ก๐ž ๐ฌ๐š๐ฆ๐ž ๐ก๐ž๐ซ๐›๐š๐ฅ๐ข๐ฌ๐ญ ๐ƒ๐ซ ๐€๐ฃ๐ž๐ ๐ก๐ž ๐›๐ž๐œ๐š๐ฎ๐ฌ๐ž ๐ข ๐ค๐ง๐จ๐ฐ ๐ญ๐ก๐š๐ญ ๐ง๐š๐ญ๐ฎ๐ซ๐ž ๐ก๐š๐ฌ ๐ญ๐ก๐ž ๐ฉ๐จ๐ฐ๐ž๐ซ
    ๐ญ๐จ ๐ก๐ž๐š๐ฅ ๐ž๐ฏ๐ž๐ซ๐ฒ๐ญ๐ก๐ข๐ง๐ .
    ๐ข ๐œ๐จ๐ง๐ญ๐š๐œ๐ญ๐ž๐ ๐ก๐ข๐ฆ ๐ญ๐จ ๐ค๐ง๐จ๐ฐ ๐ก๐จ๐ฐ ๐ก๐ž ๐œ๐š๐ง ๐ก๐ž๐ฅ๐ฉ ๐ฆ๐ž ๐š๐ง๐ ๐ก๐ž ๐ญ๐จ๐ฅ๐ ๐ฆ๐ž ๐ง๐ž๐ฏ๐ž๐ซ ๐ญ๐จ ๐ฐ๐จ๐ซ๐ซ๐ฒ
    ๐ญ๐ก๐š๐ญ ๐ก๐ž ๐ฐ๐ข๐ฅ๐ฅ ๐ก๐ž๐ฅ๐ฉ ๐ฆ๐ž ๐ฐ๐ข๐ญ๐ก ๐ญ๐ก๐ž ๐ง๐š๐ญ๐ฎ๐ซ๐š๐ฅ ๐ก๐ž๐ซ๐›๐ฌ ๐œ๐ซ๐ž๐š๐ญ๐ž๐ ๐›๐ฒ ๐†๐จ๐ ๐€๐ฅ๐ฆ๐ข๐ ๐ก๐ญ๐ฒ!
    ๐š๐Ÿ๐ญ๐ž๐ซ ๐Ÿ ๐๐š๐ฒ๐ฌ ๐จ๐Ÿ ๐œ๐จ๐ง๐ญ๐š๐œ๐ญ๐ข๐ง๐  ๐ก๐ข๐ฆ, ๐ก๐ž ๐ญ๐จ๐ฅ๐ ๐ฆ๐ž ๐ญ๐ก๐š๐ญ ๐ญ๐ก๐ž ๐œ๐ฎ๐ซ๐ž ๐ก๐š๐ฌ ๐›๐ž๐ž๐ง ๐ฉ๐ซ๐ž๐ฉ๐š๐ซ๐ž ๐š๐ง๐
    ๐ก๐ž ๐ฐ๐ข๐ฅ๐ฅ ๐ฌ๐ž๐ง๐ ๐ข๐ญ ๐ญ๐จ ๐ฆ๐ž ๐ฏ๐ข๐š (๐…๐ž๐๐„๐ฑ ๐ƒ๐ž๐ฅ๐ข๐ฏ๐ž๐ซ๐ฒ ๐ฌ๐ž๐ซ๐ฏ๐ข๐œ๐ž)๐š๐ง๐ ๐ข๐ญ ๐ ๐จ๐ญ ๐ญ๐จ ๐ฆ๐ž ๐š๐Ÿ๐ญ๐ž๐ซ ๐Ÿ‘ ๐๐š๐ฒ๐ฌ!
    ๐ข ๐ฎ๐ฌ๐ž๐ ๐ญ๐ก๐ž ๐ฆ๐ž๐๐ข๐œ๐ข๐ง๐ž ๐š๐ฌ ๐ก๐ž ๐ข๐ง๐ฌ๐ญ๐ซ๐ฎ๐œ๐ญ๐ž๐ ๐ฆ๐ž (๐Œ๐Ž๐‘๐๐ˆ๐๐† ๐š๐ง๐ ๐„๐•๐„๐๐ˆ๐๐†) ๐š๐ง๐ ๐ข ๐ฐ๐š๐ฌ
    ๐œ๐ฎ๐ซ๐ž๐!
    ๐ข๐ญ๐ฌ ๐ซ๐ž๐š๐ฅ๐ฅ๐ฒ ๐ฅ๐ข๐ค๐ž ๐š ๐๐ซ๐ž๐š๐ฆ ๐›๐ฎ๐ญ ๐ข ๐š๐ฆ ๐ฌ๐จ ๐ก๐š๐ฉ๐ฉ๐ฒ ๐ง๐จ๐ฐ!
    ๐ญ๐ก๐š๐ญ'๐ฌ ๐ญ๐ก๐ž ๐ซ๐ž๐š๐ฌ๐จ๐ง ๐ข ๐๐ž๐œ๐ข๐๐ž๐ ๐ญ๐จ ๐š๐ฅ๐ฌ๐จ ๐š๐๐ ๐ฆ๐จ๐ซ๐ž ๐œ๐จ๐ฆ๐ฆ๐ž๐ง๐ญ ๐จ๐Ÿ ๐‡๐ข๐ฆ ๐ฌ๐จ ๐ญ๐ก๐š๐ญ ๐ฆ๐จ๐ซ๐ž ๐œ๐š๐ง
    ๐›๐ž ๐ฌ๐š๐ฏ๐ž๐ ๐ฃ๐ฎ๐ฌ๐ญ ๐ฅ๐ข๐ค๐ž ๐ฆ๐ž!
    ๐š๐ง๐ ๐ข๐Ÿ ๐ฒ๐จ๐ฎ ๐ง๐ž๐ž๐ ๐ก๐ข๐ฌ ๐ก๐ž๐ฅ๐ฉ, ๐ฒ๐จ๐ฎ ๐œ๐š๐ง ๐ž๐ฆ๐š๐ข๐ฅ ๐ก๐ข๐ฆ ๐จ๐ง ๐›๐š๐›๐š๐š๐ฃ๐ž๐ ๐ก๐ž๐ฌ๐ก๐ซ๐ข๐ง๐ž@๐ ๐ฆ๐š๐ข๐ฅ.๐œ๐จ๐ฆ
    ๐จ๐ซ ๐ฐ๐ก๐š๐ญ๐ฌ-๐š๐ฉ๐ฉ +๐Ÿ๐Ÿ‘๐Ÿ’๐Ÿ•๐ŸŽ๐Ÿ–๐Ÿ‘๐Ÿ—๐Ÿ–๐Ÿ’๐Ÿ’๐Ÿ—๐Ÿ’
    ๐ˆ'๐ฆ ๐ฏ๐ž๐ซ๐ข๐ญ๐š ๐‘๐จ๐›๐ž๐ซ๐ญ๐ฌ ๐š๐ง๐ ๐ฒ๐จ๐ฎ ๐œ๐š๐ง ๐ ๐ž๐ญ ๐ข๐ง ๐ญ๐จ๐ฎ๐œ๐ก ๐ฐ๐ข๐ญ๐ก ๐ฆ๐ž ๐ฏ๐ข๐š ๐ฆ๐š๐ข๐ฅ / ๐ข๐ง๐ฌ๐ญ๐š๐ ๐ซ๐š๐ฆ (@๐ฏ๐ž๐ซ๐ข๐ญ๐š๐ซ๐จ๐›๐ž๐ซ๐ญ) ๐ฏ๐ž๐ซ๐ข๐ญ๐š๐ซ๐จ๐›๐Ÿ๐Ÿ•@๐ ๐ฆ๐š๐ข๐ฅ.๐œ๐จ๐ฆ

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  16. I'm so excited to share my testimonies about the Good Work of  Dr. Anuge who got me cured from herpes simplex virus (HSV1&2) with his herbs, I never thought that I would live on earth before the year runs out. I have been suffering from herpes, I had spent a lot of money going from one Hospital to another looking for a way to get rid of this disease, the hospital has been my home everyday residence. Constant checks up have been my hobby not until this fateful day, I was searching through the internet, I saw a testimony on how @Dr_anuge7 helped someone in curing his herpes disease using his healing Herbs, quickly I copied his email just to give him a test I spoke to him, he told me that he is going to provide the herbal cure to me, which he did, after I received his herbs and I took it as instructed. I was cured permanently from herpes. My herpes disease was gone. so I decided to share my testimony, that nothing is impossible with God, God used a man to heal me. No matter what you are passing through, no matter how deadly the sickness is and no matter what the situation is God that did mine is still going to do yours, people suffering from herpes, brain tumor, kidney disease, pcos, AIDS, ALS, copd, asthma, arthritis, herpes, Cancer, Hpv, any kind of disease, you can reach him now via Gmail address: dranuge@gmail.com or whatsapp   +2348164866838

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  17. FINALLY FREE FROM HERPES VIRUS
    I thought my life had nothing to offer anymore because lifebecame meaningless to me because I had Herpes virus, thesymptoms became very severe and bold and made my familyrun from and abandoned me so they won't get infected. I gaveup everything, my hope, dreams,vision and job because thedoctor told me there's no cure. I consumed so many drugs butthey never cured me but hid the symptoms inside me makingit worse. I was doing some research online someday when Icame across testimonies of some people of how DR Ebhotacured them from Herpes, I never believed at first and thoughtit was a joke but later decided to contact him on the detailsprovided and when I messaged him we talked and he sent mehis herbal medicine and told me to go for a test after twoweeks. Within 7 days of medication the symptomsdisappeared and when I went for a test Lo and behold I wasNEGATIVE by the Doctor Who tested me earlier. Thank you DREbhota because I forever owe you my life and I'll keep ontelling the world about you. If you are going through samesituation worry no more and contact DR Ebhota viadrebhotasolution@gmail. com or WhatsApp him via +2348089535482.he also special on cureing 1. HIV/AIDS2. HERPES 3. CANCER 4.ALS 5. HEPATITIS B 6.DIABETES 7. HUMAN PAPILOMA VIRUS DISEASE(HPV)8. ALZHEIMER 9. LUPUS (Lupus Vulgaris or LupusErythematosus

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  18. Good news this is to everyone out there with different health challenges, as I know there are still a lot of people suffering from different health issues and are therefore looking for solutions. I bring you Good news. There is a man called Dr ehiaguna a herbal practitioner who helped cure me from HSV (2), i had suffered from this diseases for the past 5 years and i have spent so much money trying to survive from it. I got my healing by taking the herbal medicine Dr ehiaguna sent to me to drink for about 14 days . 3 days after completion of the dosage, I went for a medical checkup and I was tested free from HSV. all thanks to God for leading me to Dr ehiaguna who was able to cure me completely from this deadly diseases, I’m sharing this so that other people can know of this great healer called Dr ehiaguna because I got to know him through elizabeth who he cured from HIV. I was made to understand that he can cure several other deadly diseases and infections. Don’t die in ignorance or silent and don’t let that illness take your life. Contact Dr ehiaguna through his email  drehiaguna@gmail.com You can also whatsapp/call him on:+2348073908953 . Visit his website  https://effectiveherbalcurehome.blogspot.com/   He cure all forms of disease {1}HIV/AIDS {2}DIABETES {3}EPILEPSY {4} BLOOD CANCER {5} HPV {6} BRAIN TUMOR {7} HEPATITIS {8}COPD{9} SICKLE AND ANAEMIA.etc Be kind enough to share as you received.  

    ReplyDelete
  19. Hello, I want to write a little review about the good work of doctor Ojamo, who cured me from HSV 1&2 for just 2 week with his herbal medicine, I never believe I can be cured again and have a good life like others, I always regretted the day I got diagnose with this virus, I become lost of hope when my doctor told me there is no cure for it, Well I am so grateful for my helper who get me cured with his herbal medicine, I went online in search of anything that can help me because I can’t deal with it forever so I found dr Ojamo email dr.ojamoherbalhome@gmail.com on a blog of someone who was cured by him,of the same herpes, so I quickly contacted him for help and explained all my pains to him, he told me not to worry about it there is a cure for real, I never believe until he sent me the herbs when I ordered for it and I got it within 5 working days that is how I took the medicine for 2 weeks and the following week I went for a test just to confirm I was 100% cured from this sickness what a miracle in my life, I am so happy right now, and forever greatful, you can also get in contact with him if you have such sickness through his whatsapp +2349077406037 or email address:: dr.ojamoherbalhome@gmail.com

    ReplyDelete
  20. I AM SO VERY HAPPY TODAY!!! That is why am giving this big thanks to Dr. sikies for curing me from HERPES. I have been suffering from HERPES for the past six (6)years and i tried everything possible to get myself cured but i could’nt get any solution! until i decided to try herbal cure. That was how i got in contact with this great herbal doctor in an online research, i contacted him and demand for the cure and he send me the cure through FedEx and gave me instructions on how to use it and after one week of taking the herbal medicine of Dr. sikies i went to the hospital for check and to God be the glory i tested HERPES negative, (I am so glad to see myself HERPES negative once again). I’m very proud to express my happiness through this platform and to say a big thanks to Dr. sikies for restoring my life back to normal. You can as well contact Dr. sikies via email: drsikies@gmail.com if you are infected with HERPES virus or having any health problems you can contact Dr. sikies and he will help you. DOCTOR SIKIES CAN AS WELL CURE THE FOLLOWING DISEASE:1. HIV/AIDS
    2. HERPES
    3. CANCER of all kind
    4. HSV 1&2
    5. Herpatitis B
    6.Diabetes
    7.HPV
    8.COPD (Chronic Obstructive Pulmonary Disease)
    9.Asthma10.Acute angle-closure Glaucoma
    11.Sickle cells
    12.CHRONIC PANCREATITIS Dr. sikies is capable of curing any type of diseases with his herbal medicine.

    Here is his website:https://drsikiesherbalcure.weebly.com

    You can reach me via mail: jasminegordillo3@gmail.com

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  21. Happiness is all I see now I never thought that I will be cured from HERPES virus again. I have been suffering from a deadly disease (HERPES) for the past 4 years now, I have spent a lot of money going from one place to another, from church to church, hospitals have been my home every day. Constant checks up have been my hobby not until this fateful day, I was searching through the internet, I saw a testimony on how DR Omongbe helped someone in curing his HERPES disease, quickly I copied his email which is dromongbenaturalremedies@gmail.com just to give him a test I spoke to him, he asked me to do some certain things which I did, he told me that he is going to provide the herbal cure to me, which he did, then he asked me to go for medical checkup after some days after using the herbal cure, behold I was free from the deadly disease, he only asked me to post the testimony through the whole world, faithfully am doing it now, please brothers and sisters, he is great, I owe him in return. if you are having a similar problem just email him on ( dromongbenaturalremedies@gmail.com ) or you can whatsApp his mobile number on +2348050407265  Visit his website  https://dromongbenaturalre.wixsite.com/dromongbenaturalreme 

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  22. Good New Everyone !! I'm here to testify about Dr AIre I was suffering from Herpes Simplex Virus for about 4 years and I was cured by Dr Aire He sent me the medicine through DHL, I got the medicine and He instructed me on how I'm going to take the medicine, He asked me to drink for 14days which was 2weeks and I did according to his instructions, that was how I got Rid of Herpes Simplex Virus permanently, You can also contact him to get HIV/AIDS medicine by calling him or texting him on WhatsApp through this number +2347036740271 or Kindly Email him directly on; drairehome@gmail.com or https://mobile.facebook.com/drairehome48

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  23. I'm 40 years old female I tested genital herpes (HSV1-2) positive in 2016. I was having bad outbreaks. EXTREMELY PAINFUL. I have try different kinds of drugs and treatment by the medical doctors all to know was avail. Six months ago I was desperately online searching for a helpful remedies for genital herpes (HSV1-2) cure, which I come across some helpful remedies on how Dr OYAGU have help so many people in curing genital herpes (HSV1-2) with the help of herbal treatment because I too believe there is someone somewhere in the world who can cure herpes completely. At of the past 2 months, however, I've been following his herpes protocol Via oyaguherbalhome@gmail.com or +2348101755322 and it stopped all outbreaks completely! To my greatest surprise I was cured completely by following the protocol of his herbal medicine . Don't be discouraged by the medical doctors. There is a cure for HSV with the help of herbs and roots by a herbalist Dr call Dr OYAGU he is so kind and truthful with his herbal treatment, kindly contact him for more information Via oyaguherbalhome@gmail.com or WhatsApp DR on +2348101755322 or visit his website https://oyaguspellcaster.wixsite.com/oyaguherbalhome you will be lucky as I am today

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  24. DR OYAGU herbal medicine is a good remedy for herpes simplex virus cure. My name is MIGNON WRIGHT , am from USA,I am here to give my testimony about DR OYAGU who helped me in my life, i want to inform the public how i was cured from (HERPES SIMPLEX VIRUS) by DR OYAGU, i visited different hospital but they gave me list of drugs like Familiar, Zovirax, and Valtrex which is very expensive to treat the symptoms and never cured me. I was browsing through the Internet searching for remedy on HERPES and i saw comment of people talking about how DR OYAGU cured them, when i contacted him he gave me hope and send a Herbal medicine to me that i took and it seriously worked for me, am a free person now without any problem, my HERPES result came out negative, I pray to God to never let me and my family forget you in our life, am now cured permanently, you can also get your self cured my friends if you really need this doctor help, you can reach him on his website ;https://oyaguspellcaster.wixsite.com/oyaguherbalhome Email: oyaguherbalhome@gmail.com or via whatsapp +2348101755322

    ReplyDelete
  25. I has suffered for Human papillomavirus HPV) for 2years, I was given some tablets at the hospital but I refused to take it, They said I have to be on it for life so I don't want take a drugs everyday for life. No point in taking medicine everyday when u won't get cure from it and I was advice to seek for natural herbal cure, after some time I found dr onokun is the most trustful herbalist that have herbs to cure wicked symptom's,I emailed dr onokun, for 2weeks been his patient he cured my (HPV) with his herbal. I only used his natural herbs for two weeks it was 100% cure. I'm not (HPV) patient anymore. I'm happy about it i finally got cured out of this mess been in my body for 2years. I also recommend you if you're living with (HPV) or herpes symptoms i also want you to be free contact dr onokun with the email attach to my post. Dronokunherbalcure@gmail.com or website www.Dronokunherbalcure.wordpress.com or facebook: https://www.facebook.com/naturaltreatmentcenter1/

    ReplyDelete
  26. Good luck to anyone reading this true life story of mine, I Was Diagnosed With type 2 Herpes Virus Last year, And I Was Looking For Solution To Be Cured Luckily I Saw Testimonies On How Dr OYAGU Cure Herpes Virus I Decided To Contact Dr OYAGU I Contacted Him He Prepared A Herbal Medicine Portion And Sent It To Me, I Started The Herbal Medicine For My Health. He Gave Me Step By Step Instructions On How To Apply It, When I Applied It As Instructed, I Was Cured Of This Deadly Herpes Within 2 weeks, I Am Now Herpes Negative. My Brother And Sister I No That There Are So Many People That Have The Same Herpes Virus Please contact Dr OYAGU To Help You Too, And Help Me To Thank Dr OYAGU For Cure Me, I’m Cured By Dr. OYAGU Herbal Medicine, His Contact Email:oyaguherbalhome@gmail.com or visit his website https://oyaguspellcaster.wixsite.com/oyaguherbalhome Or Cell Whatsapp Number +2348101755322 thank you

    ReplyDelete
  27. Attractive section of content. I simply stumbled upon your blog and in accession capital to assert that I acquire in fact enjoyed
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    (jk)


    ReplyDelete
    Replies
    1. Good news this is to everyone out there with different health challenges, as I know there are still a lot of people suffering from different health issues and are therefore looking for solutions. I bring you Good news. There is a man called Dr ehiaguna a herbal practitioner who helped cure me from HSV (2), i had suffered from this diseases for the past 5 years and i have spent so much money trying to survive from it. I got my healing by taking the herbal medicine Dr ehiaguna sent to me to drink for about 14 days . 3 days after completion of the dosage, I went for a medical checkup and I was tested free from HSV. all thanks to God for leading me to Dr ehiaguna who was able to cure me completely from this deadly diseases, I’m sharing this so that other people can know of this great healer called Dr ehiaguna because I got to know him through elizabeth who he cured from HIV. I was made to understand that he can cure several other deadly diseases and infections. Don’t die in ignorance or silent and don’t let that illness take your life. Contact Dr ehiaguna through his email drehiaguna@gmail.com You can also whatsapp/call him on:+2348073908953 .He cure all forms of disease {1}HIV/AIDS {2}DIABETES {3}EPILEPSY {4} BLOOD CANCER {5} HPV {6} BRAIN TUMOR {7} HEPATITIS {8}COPD{9} SICKLE AND ANAEMIA.etc Be kind enough to share as you received.

      Delete

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