Saturday, January 10, 2015

Where Are the Schizophrenia Genes?

Schizophrenia is another one of those conditions (like alcoholism) that we're constantly being told is highly heritable, based on the results of twin studies and various other findings (from studies that pre-date the DNA-sequencing era). Studies "proving" the heritability of schizophrenia are, in general, rarely questioned, or even reviewed critically, due to the fact that a genetic basis for schizophrenia makes so much intuitive sense and agrees so well with ordinary experience. Everybody knows someone who "has schizophrenia in their family," and it very much does seem to travel in families.

The fact that something travels in families is not automatically indicative of a genetic connection, but most people aren't ready to believe such a thing since it goes against common sense. Nevetheless, in the past few decades, a great deal of work (much of it quite compelling) has gone into the study of things like intergenerational trauma, with researchers finding, for example, that the course of PTSD in modern-day Israeli military veterans is much different for soldiers whose parents or grandparents were Holocaust survivors. (I talk about intergenerational trauma in Of Two Minds. In fact, there's a whole chapter on Trauma.)

Social workers and criminologists have known for years that childhood physical and sexual abuse tend to be intergenerational. Yet no one seriously suggests there's a "child abuse gene" or a "child molestation gene." A lot of things that aren't purely genetic are trans-generational; familial. Schizophrenia itself may be in this category. The links between childhood trauma and schizophrenia are quite strong and well known. Indeed, the literature shows that the associations between childhood trauma and schizophrenia are actually as strong as or stronger than the associations between childhood trauma and other disorders that we know have a high correspondence to childhood trauma (including depression, PTSD, anxiety disorders, dissociative disorders, eating disorders, personality disorders, substance abuse, and sexual dysfunction, among others).

Still, the search for "schizophrenia genes" goes on, and every so often we hear claims for this or that group of scientists having discovered some new genetic feature that confers high risk for schizophrenia. The latest of these reports comes from the Schizophrenia Working Group of the Psychiatric Genomics Consortium, which published a piece in Nature Letters in July 2014 called "Biological insights from 108 schizophrenia-associated genetic loci." The report trumpets the finding of "108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported." This is a genome-wide association study, subject to the usual GWAS caveats.

Of the 108 loci, 75% were associated with protein-coding genes, a very high number for a GWAS study, and quite a few genes involve physiologically relevant functions.

On the surface, it sounds promising.

Where things start to fall down is in determining how much heritability risk the 108 loci can account for. The authors said: "Assuming a liability-threshold model, a lifetime risk of 1%, independent SNP effects, and adjusting for case-control ascertainment, RPS" (risk profile scores) "now explain about 7% of variation on the liability scale to schizophrenia across the samples, about half of which (3.4%) is explained by genome-wide significant loci." To parse that: We know the lifetime risk of schizophrenia is 1%. If we total up the disease risk attributable to all of the 128 markers found in the study, we can explain 7% of schizophrenia risk. But if we limit ourselves to the 108 markers that met criteria for genome-wide significance (a stringent test intended to reduce the risk of false positives), we can explain only a little more than 3% of schizophrenia risk.

So once again, it's a mixed bag: a genome-wide association study (GWAS) that's filled with interesting findings (some of which may prove to be important), but that fails, quite miserably, to explain heritability.

Many people have commented on the possible reasons why genome-wide association studies have been hit-or-miss in their ability to explain heritability, why they so often find SNPs (single nucleotide polymorphisms) that don't map to genes, why the results often don't replicate well, etc. I think if we're honest, we have to admit that GWAS isn't always the right tool for the job. It's a great tool, but you have to remember how it works. GWAS attempts to match fairly common (i.e., occurring in 1% or more of the population) single nucleotide polymorphisms (which you can think of as point mutations) in databases that have been specially built to accommodate the most common polymorphisms. In a GWAS, you aren't doing deep sequencing of people's genes; you're looking for markers that cover a rather tiny percent of the genome. These markers occur commonly, which almost by definition prevents them from being very serious defects, because serious genetic defects are rendered rare by evolution (natural selection removes them from the gene pool over time). Therefore, in a technique that, by design, looks mainly at commonly occurring SNPs, which are overwhelmingly neutral (from an evolutionary standpoint), we should not be surprised to find that the markers that get spotted in GWAS (as genome-wide significant) are essentially neutral mutations without much phenotypic effect.

Unfortunately, we're at an awkward point in the history of science, because technology has given us some powerful DNA analysis tools (and the computers needed to crunch the data), but we're not quite yet at the point where detailed, deep genetic sequencing of whole human genomes is economically feasible for a study that includes, say, a thousand cases and a thousand controls. (Right now, it costs about $10,000 to do the necessary sequencing.) When a human genome can be reliably sequenced for under $2000, we'll have the tools to do really serious, deep genetic studies of hard-to-pin-down diseases. Whether we'll have the computer power needed to do the necessary statistical analysis on the scale of large (N > 1000) case-control studies is another matter; remember that in GWAS we're dealing with perhaps 500,000 data points per genome whereas in deep sequencing we're generating billions of data points per genome. It'll probably be doable using Amazon AWS/EC2 infrastructure (or Google's compute-cloud). Another reason to invest in Amazon, probably.

I'm in the process of writing a 100,000-word book on mental illness. It's evidence-based; part science, part memoir, with over 200 footnotes (so you can refer to the scientific literature yourself). To follow the progress of the book, check back here often, and also consider adding your name to our mailing list. Thanks!

36 comments:

  1. Upon reading your article, I can't help but think that if they understood statistics, people would not make the mistake of thinking that twin studies or GWAS prove a genetic link. Neither has the statistical power to exclude other causes/links.

    ReplyDelete
    Replies
    1. ALL THANKS TO DR WILLIAMS WITH HIS HERB I WAS CURED FROM A TERRIBLE TINNITUS.
      . Is my pleasure to comment on this site and i thank the admin of this site for his/her great work so far. I really don’t know how to thank DR WILLIAMS for helping me get cured for over 20 year of suffering from a terrible tinnitus, my tinnitus started when i was 28 year i thought is going to end one day but even get worse as days went by,i have tried all western drugs prescribed by doctors but to no avail i lost total concentration, even at night i screams even more because the sounds become louder because everywhere is quiet. i came across DR WILLIAMS contact through a headline news on internet about how DR WILLIAMS have help so many people to get cured of tinnitus and so many other with similar body problem ,i contacted him and he told me how to get his herb,few day later he sent me the herbal portion which i take every morning for 21 days, and his medicine was able to restore me back to normal and now am very okay without any side effects whatsoever If you have Tinnitus, you can contact him on his email address drwilliams098765@gmail.com for help

      Delete
    2. There is a saying which says "When there is Live there is hope for the future".
      This vibes has been motivating my spirit and keeping me stronger the more even when I am in pains and in tears. I am Glenna Trish from Ohio, US. My life turned upside down when I found out I was having Fibroid in me and the doctor said I have to undergo surgery in other to remove it but it's going to come up after some months, inside me my heart was burning like a fire because I don't want go for any surgery. I keep researching everyday on the internet and keep asking people around me explaining my problem to them to see if they could help me out, I did this for almost two months no result was coming out. One Faithful Morning, when I was in the Church, I met this lady who later called me after service and she told me she saw when I was busy browsing researching about how to get cure to Fibroid without surgery inside the Church, I told her yes if she could help out? She answered Yes, Inside me I was happy at last I have found a way out on how to get rid of this problem, he told me about Doctor Patrick, how he met him and how she was cured too from Fibroid that she was once a patient and his medicines has no side or bad effects. She said to me that doctor Patrick can help me out too, if only I use his herbal medicine, everything is going to be fine and is not going to come up anymore and the cure last forever. I was so happy and I took the details of the doctor, when I got home I visit his website http://patrickherbalhealinghome.my-free.website and read more about him and after that, I contacted him, I paid for the medicine and the tracking number which he used to send the medicine through DHL Courier was given to me, after three days I received it, and I read the instructions, and started using this powerful herbal medicine, I was so surprise that after one week of taking this medicine, have already started seeing changes in my body, I continued using it according to his command for two weeks and after two weeks of using it, I called the family doctor to come and run test on me, I was so surprised when he told me that he can find anything anymore that I have been cured already and there is nothing showing up, I thought he was playing, I visited two extra hospitals and they said the same thing, I took the phone and called Doctor Patrick immediately and thank him for what he has done for me, in fact, he was sent by God to heal me and save my Marriage Life. Contact doctor today if you are having any issues with your
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      Delete
  2. Family therapists witnessed recovered patients return to their prior state when they rejoined their family. Some spouses showed signs of mental illness when the schizophrenic recovered also. See writing of Carl Whittaker.
    Darlene Lancer, LMFT
    Author of "Codependency for Dummies"
    http://whatiscodependency.com

    ReplyDelete
    Replies
    1. Triggers. I can say that it's best for me to keep family at a distance i.e. father and sisters.

      Delete
  3. Schizophrenia develops as a result of being a victim of a psychopath. Psychopathy runs in families. Correlation?

    ReplyDelete
  4. I believe it is caused by childhood trauma and adult trauma as well.

    ReplyDelete
  5. Am one of the happiest Father on earth,My son onces suffered from the problem Schizophrenia which made him not to go to school,and that was killing his educational carrier.he can not control his emotions,always having nosies on his head affect how he thinks, feels and acts,he has taken different medication,but no cure,then i got the contact of a doctor who helped my son. he gave me the medication which my son used, he took the medication for two weeks,and that was the end of the problem.he can now control his emotions,no more severely distorted self-image and feeling worthless acts, his thinking is normal and no more voices on his head any more.any one that need his medication should contact the Doctor on benardleo13@gmail.com

    ReplyDelete
  6. Am one of the happiest Father on earth,My son onces suffered from the problem Schizophrenia which made him not to go to school,and that was killing his educational carrier.he can not control his emotions,always having nosies on his head affect how he thinks, feels and acts,he has taken different medication,but no cure,then i got the contact of a doctor who helped my son. he gave me the medication which my son used, he took the medication for two weeks,and that was the end of the problem.he can now control his emotions,no more severely distorted self-image and feeling worthless acts, his thinking is normal and no more voices on his head any more.any one that need his medication should contact the Doctor on benardleo13@gmail.com

    ReplyDelete
  7. This is good news to all, My son who has F23.1 type of Schizophrenia is finally cure. Is this a miracle, They told me Schizophrenia can never be cure, can professional here explain this to me. The Herbal medication I use for my son worked perfectly on him and now I have peace at home now, My son is finally healed. If you have someone with a chronic type of Schizophrenia, contact Dr. Justin with this e-mail (rodwenhill080@gmail.com)

    ReplyDelete
  8. I decided to share this to help someone out there who is still held with schizophrenia.
    My son suffered from chronic schizophrenia for 18 years and we travelled round the world from one hospital to another neurologist and spent thousands of dollars and even got scammed in ths process of seeking a cure and the peroblem still persisted. He acted weird and aggresive and this was so scary. All thanks to Dr Joseph who was able to use his medicine to cure him permanently. He is one of the Honest men out there. If you want to contact him on how to get his medicine or for info just reach him directly on josephalberteo@gmail.com Thanks admin.

    ReplyDelete
  9. DR WILLIAMS HERBAL CURE TO TINNITUS

    Appreciation is the key to doing more that is why I have took some time out to thank some one who cured me of my 4 years tinnitus problem. It became a major problem to me as it was affecting my marital life and I was no longer comfortable so I decided to look for a solution and I came across a post of Dr williams and how he has been helping people of the same problem with his herbal remedies I contacted him and told him all I have been facing in my life. He told me how to get his product and how to take it after every thing I find out that all was now okay with me and that my tinnitus problem was gone that is why I have come out today to say thank you to him and for any tinnitus problem either from man or woman. Contact him on drwilliams098765@gmail.com his a man that take good care of his children

    ReplyDelete
  10. nice write up! I suffered from dementia, I was like a Psycho, I sought help from DR Jose Alessio, with his drugs, prayers and instructions I was treated and now i am free!pray to God and follow the instructions of Dr Jose, he has the perfect solutions for the following ailments,SCHIZOPHRENIA,TRAUMATIC BRAIN INJURIES or TBI, DELUSIONS, BRAIN CANCER, APHASIA, AUTISM, PSYCHOSIS, PARKINSON'S DISEASE AND STROKES.He is such a genius dealing with brain issues, you can write to him on joseherbals28@gmail.com He will surely be able to help you

    ReplyDelete
  11. COMPLETE CURE TO TINNITUS: I had tinnitus in both ears for fifteen years with a high pitched two tone sound, the noises are constant and have learned to ignore the ringing. Later, another sound was added, a deep tone that has a sporadic rhythm, that mimics human speech. It varies from soft and muted, to painfully clear, and loud. Have try sound machines, ear plugs, my hearing aid, and medication all to no avail rather I have a difficult time sleeping. Lately I was directed to a Doctor called William on internet who provided solution to the problem. Do not be discourage, dr williams product is a permanent cure to Tinnitus. Contact him with this email (drwilliams098765@gmail.com)

    ReplyDelete
  12. WE WELCOME YOU ALL TO DEVANSH HERBAL HEALTH CARE.
    We have Quality Rick Simpson Cannabis oil and medical marijuana for smokers, all types of cancer cure, insomnia,fibroid,Diabetes,tinnitus,epilepsy,back pain,we also have the herbs that reduces stress and other illness. We are selling our products at very negotiable and workable prices. Apart from our very magnificent prices, when you buy from us, you are assured of the highest quality and purity available in the market,and we are 100% sure of our product, with a guaranteed discreet courier shipping or a special 24 hours confidential overnight delivery of the product to your address. We respect and value your privacy and will dont share your information with anyone. We offer discreet and Reliable packaging and delivery. -Fast and reliable shipment within 24hours within the US and 48 hours internationally, using courier service. Call or Text::::: +1936-2283-155, Email: devanshherbalheathcare@gmail.com for more information

    ReplyDelete
  13. I am happy because today i am a living testimony. i want all here to know how i was cured of my schizophrenia. i was diagnosed of schizophrenia some months back. And my health begins to deteriorate gradually. It got to the extent that the symptoms was now all over my body. i have spent thousands of $$ in search for a cure but my doctor keep telling me no cure. i almost gave up. But on a very faithful day as my daughter was browsing on the internet, she saw someone who testified of how a herbal doctor by the name Doctor Ehidiamen cured him of his disease with the use of herbs. So she tried to get in contact with this doctor, and after she explain to him, he assured her that he can cure me of my schizophrenia. He gave me the steps to follow, i followed it and he prepared the herbs and send it to me in USA. i took the mixture according to his prescription and behold it worked perfectly for me. Today i am happy to say i totally cured of my schizophrenia and my family is happy together again. Please i want you all suffering from schizophrenia, or other brain related problem to also get cured just as i was cured. for this reason i want you all to contact the herbal doctor Ehidiamen. His email is email is: doctorehidiamen@gmail.com and his phone number is +2348102802949. Just explain to him what you are passing through and get his counsel and treatment. Thanks to you all.

    ReplyDelete
  14. ALL THANKS TO DR WILLIAMS WITH HIS HERB I WAS CURED FROM A TERRIBLE TINNITUS.
    . Is my pleasure to comment on this site and i thank the admin of this site for his/her great work so far. I really don’t know how to thank DR WILLIAMS for helping me get cured for over 20 year of suffering from a terrible tinnitus, my tinnitus started when i was 28 year i thought is going to end one day but even get worse as days went by,i have tried all western drugs prescribed by doctors but to no avail i lost total concentration, even at night i screams even more because the sounds become louder because everywhere is quiet. i came across DR WILLIAMS contact through a headline news on internet about how DR WILLIAMS have help so many people to get cured of tinnitus and so many other with similar body problem ,i contacted him and he told me how to get his herb,few day later he sent me the herbal portion which i take every morning for 21 days, and his medicine was able to restore me back to normal and now am very okay without any side effects whatsoever If you have Tinnitus, you can contact him on his email address drwilliams098765@gmail.com for help

    ReplyDelete
    Replies
    1. Dr Williams herbal medicine is really a complete and permanent cure to tinnitus with his herbal portion am now also free from the ringing in my ears .

      Delete
  15. ALL THANKS TO DR WILLIAMS WITH HIS HERB I WAS CURED FROM A TERRIBLE TINNITUS.
    . Is my pleasure to comment on this site and i thank the admin of this site for his/her great work so far. I really don’t know how to thank DR WILLIAMS for helping me get cured for over 20 year of suffering from a terrible tinnitus, my tinnitus started when i was 28 year i thought is going to end one day but even get worse as days went by,i have tried all western drugs prescribed by doctors but to no avail i lost total concentration, even at night i screams even more because the sounds become louder because everywhere is quiet. i came across DR WILLIAMS contact through a headline news on internet about how DR WILLIAMS have help so many people to get cured of tinnitus and so many other with similar body problem ,i contacted him and he told me how to get his herb,few day later he sent me the herbal portion which i take every morning for 21 days, and his medicine was able to restore me back to normal and now am very okay without any side effects whatsoever If you have Tinnitus, you can contact him on his email address drwilliams098765@gmail.com for help

    ReplyDelete
  16. I have had two myomectomy, abdominal in 05/2012 and laparoscopy in 02/2014. I have never been pregnant; not to my knowing. I’m feeling hopeless and the fibroids are growing again. Doctor said that it look like I may need another myomectomy. I know that I have a fibroid the size of a goose egg(6cm).so i was online looking for help when i saw a post about this dr buba who has helped many with root ans herbs so i wrote to him he gave me some advice and told me what to do which i did then he sent a bottle of a herbal drug to me through DHL which i used for seven days and today i am cured already all thanks to him if you
    are in my shoes or have any related sickness
    HIV AND AIDS
    HERPES
    CANCER
    STDS
    Etc
    CONTACT DR.BUBASPELLHOME@GMAIL.COM OR CALL +2348087937686 FOR URGENT HELP
    ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,

    ReplyDelete
  17. I am sophie from Canada, I once suffered from a terrible and Chronic tinnitus ,in 2016, the doctor told me it has no permanent cure i was given medications to slow down its progress, i constantly felt my health was deteriorating as i constantly go out of breath,and this noise was really terrible especially when am sleeping, i have this constant ringing in my ears for about 8 months, this was really a terrible noise ,on thin one day that i was going through the internet,and i came across a post of Mrs Kate on how she was been cured from tinnitus through dr Williams herbal product, I contacted this herbal doctor via his email and explain everything to him and make purchase of his product,few days later he sent me the herbal medicine through courier service, when i received the herbal medicine i used it for 3 weeks as prescribed and i was totally cured of tinnitus within those week of usage,on thin now i have not hear anything ringing in my ears.if you need his help you can Contact this herbal doctor via his email drwilliams098765@gmail.com for help

    ReplyDelete
  18. I have been in the tinnitus community for a while now and I have experience what you are going though with tinnitus , I do know people that have got
    tinnitus from having their implants done. Ringing in the ear after an implant can go away on its own, but that is BS of what the mouth and jaw specialist said. I have definitely seen and heard of a connection between tinnitus and teeth and mouth. There is a treatment for ringing ears and if you are
    interested you can contact Dr William herbal remedies that what I take that stop the ringing in my ear that was really driving me crazy, don't Lose hope .,I have found a solution for my fellow citizens . If you haven't I would suggest trying Dr William herbal supplement. Again, this is a thing that takes time and usually requires time and patience for it to work WITH no side effects. But I'm not hear to sell you the product, I'm only hear to tell you that it works, but it is a journey and can be difficult. I hope at this point in want away on it own. Good luck . his email address drwilliams098765@gmail.com for advice and for his product

    ReplyDelete
  19. I want to say a big thanks to Doctor Andre Armstead of USA for helping me cure me of my Brain disease. Brothers and sisters, Nath Luth is my name and I live in Texas USA. Few years ago I had a car accident and my brain was affected I was rushed to the hospital the doctor did his check and said I don’t have any internal injury in my brain but just that I was emotionally fragmented and for that reason I lost memory of what happened. But sometimes I sleep at night and I see in dream how I got the accident. But when dawn if am asked how it happened, I can’t say it. It continued like that and I found myself very forgetful. Doctor gave me medicines like Diuretics, Anti-seizure drugs, Coma-inducing drugs, to some extents the drugs helped but later on it stop helping me and as a result of this, I was fully diagnosed of schizophrenia (Brain Disease). Doctor said my problem was same with a variety of brain disease like salience syndrome, Psychosis, susceptibility syndrome, Asperger's Syndrome, Lemierre syndrome, Stevens Johnson Syndrome, Steele-Richardson-Olszewski syndrome, vascular dementia, CJD, mad cow disease, PTSD, encephalitis, panic disorder, OCD, ADD and a lot more. So i and my family became very afraid because doctor said I would die with it. My Immediate younger brother is an ICT officer he is always on the internet. So he came home and said he read about a herbal doctor called Doctor Andre Armstead who have used his herbal medicine to cure so many people of various diseases. So he copied out the contact details of the Dr and he contacted him. He emailed him, and explained to him what I was passing through but Dr Andre promised him that he will cure me of my brain disease and I will be totally cured for life. So he made the arrangement with Dr Andre, and he prepared the herbs from Washington and shipped it to us in Texas. So I followed his instructions on how to take it and behold it worked for me just like a magic, and totally cured me of my long suffered brain disease, and today I am totally cured of my brain disease. Please if you are out there suffering from any kind of brain disease, or you know someone suffering from it, I urge you to contact Dr Andre immediately and get your cure. His contact details are (doctorandreaarmstead@gmail.com) and his phone number is +1 (617) 663-8926, Thanks.

    ReplyDelete
  20. I have had two myomectomy, abdominal in 05/2012 and laparoscopy in 02/2014. I have never been pregnant; not to my knowing. I’m feeling hopeless and the fibroids are growing again. Doctor said that it look like I may need another myomectomy. I know that I have a fibroid the size of a goose egg(6cm).so i was online looking for help when i saw a post about this dr buba who has helped many with root ans herbs so i wrote to him he gave me some advice and told me what to do which i did then he sent a bottle of a herbal drug to me through DHL which i used for seven days and today i am cured already all thanks to him if you
    are in my shoes or have any related sickness
    HIV AND AIDS
    HERPES
    CANCER
    STDS
    Etc
    CONTACT DR.BUBASPELLHOME@GMAIL.COM FOR URGENT HELP

    ReplyDelete
  21. I have had two myomectomy, abdominal in 05/2012 and laparoscopy in 02/2014. I have never been pregnant; not to my knowing. I’m feeling hopeless and the fibroids are growing again. Doctor said that it look like I may need another myomectomy. I know that I have a fibroid the size of a goose egg(6cm).so i was online looking for help when i saw a post about this dr buba who has helped many with root ans herbs so i wrote to him he gave me some advice and told me what to do which i did then he sent a bottle of a herbal drug to me through DHL which i used for seven days and today i am cured already all thanks to him if you
    are in my shoes or have any related sickness
    HIV AND AIDS
    HERPES
    CANCER
    STDS
    Etc
    CONTACT DR.BUBASPELLHOME@GMAIL.COM FOR URGENT HELP

    ReplyDelete
  22. ALL THANKS TO DR WILLIAMS WITH HIS HERBAL PORTION I WAS COMPLETELY CURED FROM A TERRIBLE TINNITUS.
    How can I ever stop thanking Dr William for the great deed he have done for me, i got an accident when I was 27 years old, from that day on i started experience ringing ear (tinnitus) i have taken all the western drugs prescribe by various doctor but to no avail . my tinnitus was very loud in the afternoon and I sleep less at night because of this problem i stop my work, few days later i was going through the Internet and I saw a post of so many people testifying about Dr William herbal remedies on how they was being cure for over many years suffering from tinnitus the story Really motivated me that I have to speak with my husband about it, and he said i should give him a try, i contacted Dr William and explain all i have be facing in my life. He assured me that everything is going to be fine if only I can get his herbal portion, i said yes and I requested for it, few days later the herb was sent to me in Kuwait,i started using it as instructed by Dr William for me to take it for 21 Days which I did, can you imagine after talking Dr William herbal medicine for just two weeks i started experience results, it was like a miracle,and now i am permanently cure from this terrible tinnitus, i promise that am going to publish his herb on thing my last breath for the great deed he have done for me. For those with similar ear problem should please contact him on his email address drwilliams098765@gmail his a good man and am proud of him.

    ReplyDelete
  23. COMPLETE CURE TO TINNITUS: I had tinnitus in both ears for fifteen years with a high pitched two tone sound, the noises are constant and have learned to ignore the ringing. Later, another sound was added, a deep tone that has a sporadic rhythm, that mimics human speech. It varies from soft and muted, to painfully clear, and loud. Have try sound machines, ear plugs, my hearing aid, and medication all to no avail rather I have a difficult time sleeping. Lately I was directed to a Doctor called William on internet who provided solution to the problem. Do not be discourage, dr williams product is a permanent cure to Tinnitus. Contact him with this email (drwilliams098765@gmail.com)

    ReplyDelete
  24. I am Matthias lang, from Orlando u s a, i suffered from schizophrenia
    for 28 years, i lived in pain with the knowledge that i wasn't going to ever be like every normal human, i contacted so many doctors on this issue,and i have use so many western drugs prescribe by various doctors and all was no avail, because i was determined to get my life back, one day i was researching for this on internet and i saw a post about devansh herbal health care who cure different manners of diseases,including schizophrenia, I contacted him via email: devanshherbalheathcare@gmail.com and made purchase of the schizophrenia herb, i received the herb through USPS within 24 hours, when i received the herb i applied it as prescribed, and to god be the glory i was totally cured of schizophrenia within 1 months of usages,my dear brothers and sisters You do not have to suffer more just contact him for his medicine on devanshherbalheathcare@gmail.com.com he will definitely put an end to that problem of yours

    ReplyDelete
  25. I decided to share this to help someone out there who is still held with schizophrenia.
    i suffered from chronic schizophrenia for 20 years and i have traveled round the world from one hospital to another neurologist and spent a lot of money, one day I took time to search internet which i found a lot of people thanking Dr. Nelson concerning the same problem and i discussed it with my wife and she said we should give a try so we order his product which i took for some months and am very much okay now.He is one of the Honest men out there. If you want to contact him on how to get his medicine or for info just reach him directly on drdavismartin62@gmail.com

    ReplyDelete
  26. I have had two myomectomy, abdominal in 05/2012 and laparoscopy in 02/2014. I have never been pregnant; not to my knowing. I’m feeling hopeless and the fibroids are growing again. Doctor said that it look like I may need another myomectomy. I know that I have a fibroid the size of a goose egg(6cm).so i was online looking for help when i saw a post about this dr buba who has helped many with root ans herbs so i wrote to him he gave me some advice and told me what to do which i did then he sent a bottle of a herbal drug to me through DHL which i used for seven days and today i am cured already all thanks to him if you
    are in my shoes or have any related sickness
    Etc
    CONTACT DR.BUBASPELLHOME@GMAIL.COM OR CALL +2348087937686 FOR URGENT HELP

    ReplyDelete
  27. There is a saying which says "When there is Live there is hope for the future".
    This vibes has been motivating my spirit and keeping me stronger the more even when I am in pains and in tears. I am Glenna Trish from Ohio, US. My life turned upside down when I found out I was having Fibroid in me and the doctor said I have to undergo surgery in other to remove it but it's going to come up after some months, inside me my heart was burning like a fire because I don't want go for any surgery. I keep researching everyday on the internet and keep asking people around me explaining my problem to them to see if they could help me out, I did this for almost two months no result was coming out. One Faithful Morning, when I was in the Church, I met this lady who later called me after service and she told me she saw when I was busy browsing researching about how to get cure to Fibroid without surgery inside the Church, I told her yes if she could help out? She answered Yes, Inside me I was happy at last I have found a way out on how to get rid of this problem, he told me about Doctor Patrick, how he met him and how she was cured too from Fibroid that she was once a patient and his medicines has no side or bad effects. She said to me that doctor Patrick can help me out too, if only I use his herbal medicine, everything is going to be fine and is not going to come up anymore and the cure last forever. I was so happy and I took the details of the doctor, when I got home I visit his website http://patrickherbalhealinghome.my-free.website and read more about him and after that, I contacted him, I paid for the medicine and the tracking number which he used to send the medicine through DHL Courier was given to me, after three days I received it, and I read the instructions, and started using this powerful herbal medicine, I was so surprise that after one week of taking this medicine, have already started seeing changes in my body, I continued using it according to his command for two weeks and after two weeks of using it, I called the family doctor to come and run test on me, I was so surprised when he told me that he can find anything anymore that I have been cured already and there is nothing showing up, I thought he was playing, I visited two extra hospitals and they said the same thing, I took the phone and called Doctor Patrick immediately and thank him for what he has done for me, in fact, he was sent by God to heal me and save my Marriage Life. Contact doctor today if you are having any issues with your
    health on his email address HERBALMEDICALHOME@GMAIL.COM and you can read more about him on his website address http://patrickherbalhealinghome.my-free.website. His office is in USA, UK, Canada, Grenada's, West African Countries and many other countries, here is one of his worker phone number +1 302-583-2195, you can text him or call him then he will direct your call to Doctor Patrick and for those who are in West African Country and other countries you can write to one of his worker on whats-app or talk to him on call and he will direct your call to Doctor Patrick if you wish to speak to him, number is +2348113872021. Once More again Thanks to Doc. Patrick and thanks to the Lady who directed me to him.

    ReplyDelete
  28. There is a saying which says "When there is Live there is hope for the future".
    This vibes has been motivating my spirit and keeping me stronger the more even when I am in pains and in tears. I am Glenna Trish from Ohio, US. My life turned upside down when I found out I was having Fibroid in me and the doctor said I have to undergo surgery in other to remove it but it's going to come up after some months, inside me my heart was burning like a fire because I don't want go for any surgery. I keep researching everyday on the internet and keep asking people around me explaining my problem to them to see if they could help me out, I did this for almost two months no result was coming out. One Faithful Morning, when I was in the Church, I met this lady who later called me after service and she told me she saw when I was busy browsing researching about how to get cure to Fibroid without surgery inside the Church, I told her yes if she could help out? She answered Yes, Inside me I was happy at last I have found a way out on how to get rid of this problem, he told me about Doctor Patrick, how he met him and how she was cured too from Fibroid that she was once a patient and his medicines has no side or bad effects. She said to me that doctor Patrick can help me out too, if only I use his herbal medicine, everything is going to be fine and is not going to come up anymore and the cure last forever. I was so happy and I took the details of the doctor, when I got home I visit his website http://patrickherbalhealinghome.my-free.website and read more about him and after that, I contacted him, I paid for the medicine and the tracking number which he used to send the medicine through DHL Courier was given to me, after three days I received it, and I read the instructions, and started using this powerful herbal medicine, I was so surprise that after one week of taking this medicine, have already started seeing changes in my body, I continued using it according to his command for two weeks and after two weeks of using it, I called the family doctor to come and run test on me, I was so surprised when he told me that he can find anything anymore that I have been cured already and there is nothing showing up, I thought he was playing, I visited two extra hospitals and they said the same thing, I took the phone and called Doctor Patrick immediately and thank him for what he has done for me, in fact, he was sent by God to heal me and save my Marriage Life. Contact doctor today if you are having any issues with your
    health on his email address HERBALMEDICALHOME@GMAIL.COM and you can read more about him on his website address http://patrickherbalhealinghome.my-free.website. His office is in USA, UK, Canada, Grenada's, West African Countries and many other countries, here is one of his worker phone number +1 302-583-2195, you can text him or call him then he will direct your call to Doctor Patrick and for those who are in West African Country and other countries you can write to one of his worker on whats-app or talk to him on call and he will direct your call to Doctor Patrick if you wish to speak to him, number is +2348113872021. Once More again Thanks to Doc. Patrick and thanks to the Lady who directed me to him.

    ReplyDelete
  29. There is a saying which says “When there is Live there is hope for the future”.
    This vibes has been motivating my spirit and keeping me stronger the more even when I am in pains and in tears. I am Glenna Trish from Ohio, US. My life turned upside down when I found out I was having Fibroid in me and the doctor said I have to undergo surgery in other to remove it but it’s going to come up after some months, inside me my heart was burning like a fire because I don’t want go for any surgery. I keep researching everyday on the internet and keep asking people around me explaining my problem to them to see if they could help me out, I did this for almost two months no result was coming out. One Faithful Morning, when I was in the Church, I met this lady who later called me after service and she told me she saw when I was busy browsing researching about how to get cure to Fibroid without surgery inside the Church, I told her yes if she could help out? She answered Yes, Inside me I was happy at last I have found a way out on how to get rid of this problem, he told me about Doctor Patrick, how he met him and how she was cured too from Fibroid that she was once a patient and his medicines has no side or bad effects. She said to me that doctor Patrick can help me out too, if only I use his herbal medicine, everything is going to be fine and is not going to come up anymore and the cure last forever. I was so happy and I took the details of the doctor, when I got home I visit his website http://patrickherbalhealinghome.my-free.website and read more about him and after that, I contacted him, I paid for the medicine and the tracking number which he used to send the medicine through DHL Courier was given to me, after three days I received it, and I read the instructions, and started using this powerful herbal medicine, I was so surprise that after one week of taking this medicine, have already started seeing changes in my body, I continued using it according to his command for two weeks and after two weeks of using it, I called the family doctor to come and run test on me, I was so surprised when he told me that he can find anything anymore that I have been cured already and there is nothing showing up, I thought he was playing, I visited two extra hospitals and they said the same thing, I took the phone and called Doctor Patrick immediately and thank him for what he has done for me, in fact, he was sent by God to heal me and save my Marriage Life. Contact doctor today if you are having any issues with your health on his email address HERBALMEDICALHOME@GMAIL.COM and you can read more about him on his website address http://patrickherbalhealinghome.my-free.website. His office is in USA, UK, Canada, Grenada’s, West African Countries and many other countries, here is one of his worker phone number +1 302-583-2195, you can text him or call him then he will direct your call to Doctor Patrick and for those who are in West African Country and other countries you can write to one of his worker on whats-app or talk to him on call and he will direct your call to Doctor Patrick if you wish to speak to him, number is +2348113872021. Once More again Thanks to Doc. Patrick and thanks to the Lady who directed me to him.

    ReplyDelete
  30. MY NAME IS NITA.

    Dr Williams,herbal treatment is the best to shrink fibroid naturally.

    Four months ago, I was scheduled an operation to remove a fairly large uterine fibroid (approx. 8 cm), which had caused me a great deal of pelvic pain and pressure on my bladder. My doctor insisted that there was no other choice but to go under the knife and I had reluctantly agreed (after trying several medications to decrease the size of the fibroid to no avail). It was approx. 2 months prior to the surgery when my husband comes across dr williams herbal remedies which my husband found and ordered for me online. With the help of my loving husband, I followed the step and procedure on how i should be taking it. and one months later I was scheduled for an ultrasound check: it was shocking. The fibroid had completely gone, I had consulted my doctor and cancelled the surgery and with your dedicated counseling guidance I managed to completely treat the fibroid from my uterus, along with the pain and anxiety that this condition had inflicted on me. Thank you so much for your kind help,any body with similar problem should contact him on his email address drwilliams098765@gmail.com his a good man

    ReplyDelete
  31. I have large uterine fibroid and multiple fibroid all over my womb (womb measures 15cm). I had a uterine fibroid embolisation in April last year. Before this treatment my womb measured 23cm. I still suffer every month with period pain, large blood clots and heavy bleeding. I was wondering if i would ever be okay,i try medications on hospital,the fibriod stay remain the same,my husband how has been taking care of me before abandon me,because i was unable to get pregnant for him,i was praying to God to help me out,i was chatting on facebook i sure a link,of a testimony of a man,on how Dr Ebhota help him to cure her wife fibriod,with his herbal medication,for over 6 years,after dr Ebhota treatment his wife got conceive with in two months,that was how i make up my mind to contact him,when i contact him there was no respond for two days,i was waiting for his respond,the third day he respond to me,that was how i explain every thing to him,that was how we make am agreement,the following week of it,he send the herb to me,he gave me instruction on how i am going to be drinking the herbal potion,for 21 day,after the herb got finish,i went my doctor in hospital,with the doctor report shows that the fibriod has totally reduces to 3cm,immediately i call Dr Ebhota with happiness and send the cope of the result test to him,after that he also send a fertility herb to me,i am so happy,i am 3 month pregnant now,for any one out there that is passing true this problem should call him,+2349035324155 or email him,drebhota123456@gmail.com,Dr Ebhota,God we always empower you and bless you to do your good work to people.

    ReplyDelete
  32. how my wife was been save from fibroid.
    greetings from Leo my wife Emily have been suffering from fibroid for so many years now and we literally tried everything but nothing since to help,the pain she use to experience we keep her up all night she was debilitating.she have to take time off from work on many occasion i did no what to do to help i felt completely helpless.every doctor we went to only have pain med to offer.my wife have been taking med to alleviate the pain for a while now and have develop a tolerance to them. the doctor said that she we require an increase dose of the meds for them to have any measurable effect.the last thing we wanted was for her to become dependent of those darn drugs.i spent countless hours online researching natural way to treat fibroid but found no clear cut comprehensive guide on how to go exactly doing it,it wasn't until we found Dr Williams herbal medicine and have watched all the video that i think it started to make sense.i order for it online after my wife started using Dr Williams herbal medicine for a couple of weeks now she feeling a million time better she doesn't complain about the pain anymore and sleep through out the night.her energy level is rising every single day, and it only been a few weeks,fibroid is no longer an every day topics of discussion in the house and we both confident that her overall health we continue to improve,after taking Dr Williams herbal medicine she is now fibroid free,its a major relief for the both of us.we are so grateful for your treatment cant thank you enough you can email him for more information on how to get his medicine drwilliams098675@gmail.com

    ReplyDelete

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